Emerging insights of nutraceuticals as anticancer

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Nutraceuticals, Antioxidants, Cancer, Conventional treatments, Supplementation


Among the most prevalent and feared diseases concerning individuals worldwide is cancer, which has multiple pathophysiological components. Over the past few years, nutraceuticals have garnered substantial interest as potential agents against cancer owing to their diverse array of bioactive compounds and limited adverse effects. This review endeavors to present a comprehensive perspective on the growing understanding of nutraceuticals' role as promising adjuncts or alternatives in cancer treatment. The focus of this review is on illuminating the anticancer attributes found in a variety of nutraceuticals, such as polyphenols, flavonoids, carotenoids, and other bioactive compounds. Due to their nutritional value and therapeutic potential against malignant cells, several nutraceuticals have recently attracted a lot of fascination. These bioactive compounds are capable of killing cancerous cells without damaging normal cells. In conclusion, this review sheds light on the emerging insights into nutraceuticals' anticancer properties and their potential as valuable components of integrative cancer therapy. Although significant progress has been made, further investigation is warranted to fully harness the therapeutic potential of these natural compounds and enhance their clinical application in the fight against cancer.


Alam, M., Ahmed, S., Elasbali, A. M., Adnan, M., Alam, S., Hassan, M. I., & Pasupuleti, V. R. (2022). Therapeutic implications of caffeic acid in cancer and neurological diseases. Frontiers in Oncology, 12, 860508.

Arora, D., & Jaglan, S. (2016). Nanocarriers based delivery of nutraceuticals for cancer prevention and treatment: A review of recent research developments. Trends in Food Science & Technology, 54, 114-126.

Balachandran, P., & Govindarajan, R. (2005). Cancer—an ayurvedic perspective. Pharmacological Research, 51(1), 19-30.

Beer, T. M., Eilers, K. M., Garzotto, M., Egorin, M. J., Lowe, B. A., & Henner, W. D. (2003). Weekly high-dose calcitriol and docetaxel in metastatic androgen-independent prostate cancer. Journal of Clinical Oncology, 21(1), 123-128.

Castro, N. P., Rangel, M. C., Merchant, A. S., MacKinnon, G., Cuttitta, F., Salomon, D. S., & Kim, Y. S. (2019). Sulforaphane suppresses the growth of triple-negative breast cancer stem-like cells in vitro and in vivo. Cancer Prevention Research, 12(3), 147-158.

Charron, C. S., Dawson, H. D., Albaugh, G. P., Solverson, P. M., Vinyard, B. T., Solano-Aguilar, G. I., Molokin, A., & Novotny, J. A. (2015). A single meal containing raw, crushed garlic influences expression of immunity-and cancer-related genes in whole blood of humans. The Journal of Nutrition, 145(11), 2448-2455.

Chen, Q., Espey, M. G., Krishna, M. C., Mitchell, J. B., Corpe, C. P., Buettner, G. R., Shacter, E., & Levine, M. (2005). Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. Proceedings of the National Academy of Sciences, 102(38), 13604-13609.

Chiou, Y. S., Tsai, M. L., Nagabhushanam, K., Wang, Y. J., Wu, C. H., Ho, C. T., & Pan, M. H. (2011). Pterostilbene is more potent than resveratrol in preventing azoxymethane (AOM)-induced colon tumorigenesis via activation of the NF-E2-related factor 2 (Nrf2)-mediated antioxidant signaling pathway. Journal of Agricultural and Food Chemistry, 59(6), 2725-2733.

Choi, E. J., Park, J. S., Kim, Y. J., Jung, J. H., Lee, J. K., Kwon, H. C., & Yang, H. O. (2011). Apoptosis‐inducing effect of diketopiperazine disulfides produced by Aspergillus sp. KMD 901 isolated from marine sediment on HCT116 colon cancer cell lines. Journal of Applied Microbiology, 110(1), 304-313.

Cockbain, A., Toogood, G., & Hull, M. A. (2012). Omega-3 polyunsaturated fatty acids for the treatment and prevention of colorectal cancer. Gut, 61(1), 135-149.

Das, A. (2015). Anticancer effect of antimalarial artemisinin compounds. Annals of Medical and Health Sciences Research, 5(2), 93-102.

Douglas, C. C., Johnson, S. A., & Arjmandi, B. H. (2013). Soy and its isoflavones: the truth behind the science in breast cancer. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 13(8), 1178-1187.

Duvoix, A., Blasius, R., Delhalle, S., Schnekenburger, M., Morceau, F., Henry, E., Dicato, M., & Diederich, M. (2005). Chemopreventive and therapeutic effects of curcumin. Cancer Letters, 223(2), 181-190.

Erdogan, S., Turkekul, K., Serttas, R., & Erdogan, Z. (2017). The natural flavonoid apigenin sensitizes human CD44+ prostate cancer stem cells to cisplatin therapy. Biomedicine & Pharmacotherapy, 88, 210-217.

Estrela, J. M., Ortega, A., Mena, S., Rodriguez, M. L., & Asensi, M. (2013). Pterostilbene: biomedical applications. Critical Reviews in Clinical Laboratory Sciences, 50(3), 65-78.

Fangjun, L., & Zhijia, Y. (2018). Tumor suppressive roles of eugenol in human lung cancer cells. Thoracic Cancer, 9(1), 25-29.

Fasano, A., & Uzzau, S. (1997). Modulation of intestinal tight junctions by Zonula occludens toxin permits enteral administration of insulin and other macromolecules in an animal model. The Journal of Clinical Investigation, 99(6), 1158-1164.

Fathy, M., Fawzy, M. A., Hintzsche, H., Nikaido, T., Dandekar, T., & Othman, E. M. (2019). Eugenol exerts apoptotic effect and modulates the sensitivity of HeLa cells to cisplatin and radiation. Molecules, 24(21), 3979.

Ganesan, P., Matsubara, K., Ohkubo, T., Tanaka, Y., Noda, K., Sugawara, T., & Hirata, T. (2010). Anti-angiogenic effect of siphonaxanthin from green alga, Codium fragile. Phytomedicine, 17(14), 1140-1144.

Ganesan, P., Noda, K., Manabe, Y., Ohkubo, T., Tanaka, Y., Maoka, T., Sugawara, T., & Hirata, T. (2011). Siphonaxanthin, a marine carotenoid from green algae, effectively induces apoptosis in human leukemia (HL-60) cells. Biochimica et Biophysica Acta (BBA)-General Subjects, 1810(5), 497-503.

Guo, H., Xu, Y. M., Ye, Z. Q., Yu, J. H., & Hu, X. Y. (2013). Curcumin induces cell cycle arrest and apoptosis of prostate cancer cells by regulating the expression of IκBα, c-Jun and androgen receptor. Die Pharmazie-An International Journal of Pharmaceutical Sciences, 68(6), 431-434.

Hamadi, H., & Castellon, R. (2005). Oleuropein, a non-toxic olive iridoid, is an anti-tumor agent and cytoskeleton disrupter. Biochemical and Biophysical Research Communications, 334(3), 769-778.

Hussain, A., Brahmbhatt, K., Priyani, A., Ahmed, M., Rizvi, T. A., & Sharma, C. (2011). Eugenol enhances the chemotherapeutic potential of gemcitabine and induces anticarcinogenic and anti-inflammatory activity in human cervical cancer cells. Cancer Biotherapy and Radiopharmaceuticals, 26(5), 519-527.

Imran, M., Rauf, A., Abu-Izneid, T., Nadeem, M., Shariati, M. A., Khan, I. A., Imran, A., Orhan, I. E., Rizwan, M., et al. (2019). Luteolin, a flavonoid, as an anticancer agent: A review. Biomedicine & Pharmacotherapy, 112, 108612.

Ismail, N. I., Othman, I., Abas, F., H. Lajis, N., & Naidu, R. (2019). Mechanism of apoptosis induced by curcumin in colorectal cancer. International Journal of Molecular Sciences, 20(10), 2454.

Jain, R. K., Trump, D. L., Egorin, M. J., Fernandez, M., Johnson, C. S., & Ramanathan, R. K. (2011). A phase I study of the vitamin D 3 analogue ILX23-7553 administered orally to patients with advanced solid tumors. Investigational New Drugs, 29, 1420-1425.

Jansen, F. H., Adoubi, I., Kouassi Comoe, J., De Cnodder, T., Jansen, N., Tschulakow, A., & Efferth, T. (2011). First study of oral Artenimol-R in advanced cervical cancer: clinical benefit, tolerability and tumor markers. Anticancer Research, 31(12), 4417-4422.

Kakar, S. S., Ratajczak, M. Z., Powell, K. S., Moghadamfalahi, M., Miller, D. M., Batra, S. K., & Singh, S. K. (2014). Withaferin a alone and in combination with cisplatin suppresses growth and metastasis of ovarian cancer by targeting putative cancer stem cells. PloS One, 9(9), e107596.

Kalra, E. K. (2003). Nutraceutical-definition and introduction. AAPS PharmSciTech, 5(3), 25.

Kanimozhi, G., & Prasad, N. (2015). Anticancer effect of caffeic acid on human cervical cancer cells. In V. Preedy (Ed.), Coffee in health and disease prevention (pp. 655-661): Elsevier.

Khanum, F., Anilakumar, K., & Viswanathan, K. (2004). Anticarcinogenic properties of garlic: a review. Critical Reviews in Food Science and Nutrition, 44(6), 479-488.

Kim, S. H., Singh, K. B., Hahm, E. R., & Singh, S. V. (2021). The role of forkhead box Q1 transcription factor in anticancer effects of Withaferin A in breast cancer. Cancer Prevention Research, 14(4), 421-432.

Kim, S. H., & Singh, S. V. (2014). Mammary cancer chemoprevention by withaferin A is accompanied by in vivo suppression of self-renewal of cancer stem cells. Cancer Prevention Research, 7(7), 738-747.

Koschorke, A., Faraci, S., Giani, D., Chiodoni, C., Iorio, E., Canese, R., Colombo, M. P., Lamolinara, A., Iezzi, M., et al. (2019). Phenethyl isothiocyanate hampers growth and progression of HER2-positive breast and ovarian carcinoma by targeting their stem cell compartment. Cellular Oncology, 42, 815-828.

Kumar, D., Basu, S., Parija, L., Rout, D., Manna, S., Dandapat, J., & Debata, P. R. (2016). Curcumin and ellagic acid synergistically induce ROS generation, DNA damage, p53 accumulation and apoptosis in HeLa cervical carcinoma cells. Biomedicine & Pharmacotherapy, 81, 31-37.

Kuppusamy, P., Yusoff, M. M., Maniam, G. P., Ichwan, S. J. A., Soundharrajan, I., & Govindan, N. (2014). Nutraceuticals as potential therapeutic agents for colon cancer: a review. Acta Pharmaceutica Sinica B, 4(3), 173-181.

Lall, R. K., Adhami, V. M., & Mukhtar, H. (2016). Dietary flavonoid fisetin for cancer prevention and treatment. Molecular Nutrition & Food Research, 60(6), 1396-1405.

Li, Q., Xia, J., Yao, Y., Gong, D. W., Shi, H., & Zhou, Q. (2013). Sulforaphane inhibits mammary adipogenesis by targeting adipose mesenchymal stem cells. Breast Cancer Research and Treatment, 141, 317-324.

Li, Y. W., Xu, J., Zhu, G. Y., Huang, Z. J., Lu, Y., Li, X.-Q., Wang, N., & Zhang, F. X. (2018). Apigenin suppresses the stem cell-like properties of triple-negative breast cancer cells by inhibiting YAP/TAZ activity. Cell Death Discovery, 4(1), 105.

Ma, Y., Yu, W., Shrivastava, A., Alemi, F., Lankachandra, K., Srivastava, R. K., & Shankar, S. (2017). Sanguinarine inhibits pancreatic cancer stem cell characteristics by inducing oxidative stress and suppressing sonic hedgehog-Gli-Nanog pathway. Carcinogenesis, 38(10), 1047-1056.

Maalmi, H., Ordóñez-Mena, J. M., Schöttker, B., & Brenner, H. (2014). Serum 25-hydroxyvitamin D levels and survival in colorectal and breast cancer patients: systematic review and meta-analysis of prospective cohort studies. European Journal of Cancer, 50(8), 1510-1521.

Mathur, G., Nain, S., & Sharma, P. K. (2015). Cancer: an overview. Academic Journal of Cancer Research, 8(1), 1-9.

Min, K. J., & Kwon, T. K. (2014). Anticancer effects and molecular mechanisms of epigallocatechin-3-gallate. Integrative Medicine Research, 3(1), 16-24.

Mohr, S. B., Gorham, E. D., Kim, J., Hofflich, H., & Garland, C. F. (2014). Meta-analysis of vitamin D sufficiency for improving survival of patients with breast cancer. Anticancer Research, 34(3), 1163-1166.

Mondal, A., Banerjee, S., Bose, S., Mazumder, S., Haber, R. A., Farzaei, M. H., & Bishayee, A. (2022). Garlic constituents for cancer prevention and therapy: From phytochemistry to novel formulations. Pharmacological Research, 175, 105837.

Muindi, J. R., Johnson, C. S., Trump, D. L., Christy, R., Engler, K. L., & Fakih, M. G. (2009). A phase I and pharmacokinetics study of intravenous calcitriol in combination with oral dexamethasone and gefitinib in patients with advanced solid tumors. Cancer Chemotherapy and Pharmacology, 65, 33-40.

Nasri, H., Baradaran, A., Shirzad, H., & Rafieian-Kopaei, M. (2014). New concepts in nutraceuticals as alternative for pharmaceuticals. International Journal of Preventive Medicine, 5(12), 1487-1499.

Padayatty, S. J., Sun, H., Wang, Y., Riordan, H. D., Hewitt, S. M., Katz, A., Wesley, R. A., & Levine, M. (2004). Vitamin C pharmacokinetics: implications for oral and intravenous use. Annals of Internal Medicine, 140(7), 533-537.

Pan, C., Hu, Y., Li, J., Wang, Z., Huang, J., Zhang, S., & Ding, L. (2014). Estrogen receptor-α36 is involved in pterostilbene-induced apoptosis and anti-proliferation in in vitro and in vivo breast cancer. PloS One, 9(8), e104459.

Pan, X., Zhao, B., Song, Z., Han, S., & Wang, M. (2016). Estrogen receptor-α36 is involved in epigallocatechin-3-gallate induced growth inhibition of ER-negative breast cancer stem/progenitor cells. Journal of Pharmacological Sciences, 130(2), 85-93.

Picotto, G., Liaudat, A. C., Bohl, L., & Talamoni, N. T. D. (2012). Molecular aspects of vitamin D anticancer activity. Cancer Investigation, 30(8), 604-614.

Pisano, M., Pagnan, G., Loi, M., Mura, M. E., Tilocca, M. G., Palmieri, G., Fabbri, D., Dettori, M. A., Delogu, G., et al. (2007). Antiproliferative and pro-apoptotic activity of eugenol-related biphenyls on malignant melanoma cells. Molecular Cancer, 6, 1-12.

Prabhu, K. S., Bhat, A. A., Siveen, K. S., Kuttikrishnan, S., Raza, S. S., Raheed, T., Jochebeth, A., Khan, A. Q., Chawdhery, M. Z., et al. (2021). Sanguinarine mediated apoptosis in Non-Small Cell Lung Cancer via generation of reactive oxygen species and suppression of JAK/STAT pathway. Biomedicine & Pharmacotherapy, 144, 112358.

Prabhu, P. N., Ashokkumar, P., & Sudhandiran, G. (2009). Antioxidative and antiproliferative effects of astaxanthin during the initiation stages of 1, 2‐dimethyl hydrazine‐induced experimental colon carcinogenesis. Fundamental & Clinical Pharmacology, 23(2), 225-234.

Prasad, S., Gupta, S. C., Tyagi, A. K., & Aggarwal, B. B. (2014). Curcumin, a component of golden spice: from bedside to bench and back. Biotechnology Advances, 32(6), 1053-1064.

Sahin, I., Bilir, B., Ali, S., Sahin, K., & Kucuk, O. (2019). Soy isoflavones in integrative oncology: increased efficacy and decreased toxicity of cancer therapy. Integrative Cancer Therapies, 18, 1534735419835310.

Salami, A., Seydi, E., & Pourahmad, J. (2013). Use of nutraceuticals for prevention and treatment of cancer. Iranian Journal of Pharmaceutical Research, 12(3), 219-220.

Scher, H. I., Jia, X., Chi, K., De Wit, R., Berry, W. R., Albers, P., Henick, B., Waterhouse, D., Ruether, D. J., et al. (2011). Randomized, open-label phase III trial of docetaxel plus high-dose calcitriol versus docetaxel plus prednisone for patients with castration-resistant prostate cancer. Journal of Clinical Oncology, 29(16), 2191-2198.

Shin, H. J., Han, J. M., Choi, Y. S., & Jung, H. J. (2020). Pterostilbene suppresses both cancer cells and cancer stem-like cells in cervical cancer with superior bioavailability to resveratrol. Molecules, 25(1), 228.

Sirianni, R., Chimento, A., De Luca, A., Casaburi, I., Rizza, P., Onofrio, A., Iacopetta, D., Puoci, F., Andò, S., et al. (2010). Oleuropein and hydroxytyrosol inhibit MCF‐7 breast cancer cell proliferation interfering with ERK1/2 activation. Molecular Nutrition & Food Research, 54(6), 833-840.

Su, H. T., Weng, C. C., Hsiao, P. J., Chen, L. H., Kuo, T. L., Chen, Y. W., Kuo, K. K., & Cheng, K. H. (2013). Stem cell marker nestin is critical for TGF-β1-mediated tumor progression in pancreatic cancer. Molecular Cancer Research, 11(7), 768-779.

Trump, D. L., Hershberger, P. A., Bernardi, R. J., Ahmed, S., Muindi, J., Fakih, M., Yu, W. D., & Johnson, C. S. (2004). Anti-tumor activity of calcitriol: pre-clinical and clinical studies. The Journal of Steroid Biochemistry and Molecular Biology, 89, 519-526.

Tsai, P. H., Cheng, C. H., Lin, C. Y., Huang, Y. T., Lee, L. T., Kandaswami, C. C., Lin, Y. C., Lee, K. P. H., Hung, C. C., et al. (2016). Dietary flavonoids luteolin and quercetin suppressed cancer stem cell properties and metastatic potential of isolated prostate cancer cells. Anticancer Research, 36(12), 6367-6380.

Tyszka-Czochara, M., Konieczny, P., & Majka, M. (2017). Caffeic acid expands anti-tumor effect of metformin in human metastatic cervical carcinoma HTB-34 cells: implications of AMPK activation and impairment of fatty acids de novo biosynthesis. International Journal of Molecular Sciences, 18(2), 462.

Upadhyaya, B., Liu, Y., & Dey, M. (2019). Phenethyl isothiocyanate exposure promotes oxidative stress and suppresses Sp1 transcription factor in cancer stem cells. International Journal of Molecular Sciences, 20(5), 1027.

Wakimoto, R., Ono, M., Takeshima, M., Higuchi, T., & Nakano, S. (2017). Differential anticancer activity of pterostilbene against three subtypes of human breast cancer cells. Anticancer Research, 37(11), 6153-6159.

Wang, D., Upadhyaya, B., Liu, Y., Knudsen, D., & Dey, M. (2014). Phenethyl isothiocyanate upregulates death receptors 4 and 5 and inhibits proliferation in human cancer stem-like cells. BMC Cancer, 14(1), 1-12.

Yang, J., Fa, J., & Li, B. (2018). Apigenin exerts anticancer effects on human cervical cancer cells via induction of apoptosis and regulation of Raf/MEK/ERK signalling pathway. Tropical Journal of Pharmaceutical Research, 17(8), 1615-1619.

Yang, Y., Kim, B., & Lee, J. Y. (2013). Astaxanthin structure, metabolism, and health benefits. Journal of Human Nutrition and Food Science, 1(1003), 1-11.

Yun, J. H., Kim, K. A., Yoo, G., Kim, S. Y., Shin, J. M., Kim, J. H., Jung, S. H., Kim, J., & Nho, C. W. (2017). Phenethyl isothiocyanate suppresses cancer stem cell properties in vitro and in a xenograft model. Phytomedicine, 30, 42-49.

Zhou, Q., Jin, P., Liu, J., Li, S., Liu, W., & Xi, S. (2021). HER2 overexpression triggers the IL-8 to promote arsenic-induced EMT and stem cell-like phenotypes in human bladder epithelial cells. Ecotoxicology and Environmental Safety, 208, 111693.




How to Cite

Pant, S. P., & Joshi, S. (2023). Emerging insights of nutraceuticals as anticancer. International Journal of Plant Based Pharmaceuticals, 3(2), 176–182. https://doi.org/10.29228/ijpbp.30



Received 2023-04-21
Accepted 2023-08-11
Published 2023-08-16