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International Journal of Plant Based Pharmaceuticals
e‑ISSN 2791-7509 Open Access · CC BY 4.0
Vol. 2 · Issue 2 · 2022 May 11, 2022 Research Articles

Pergularia daemia (Apocynaceae) mitigates rifampicin-induced hepato-renal injury: potentials in the management of liver and kidney diseases

TO
Temidayo Ogunmoyole Corresponding Ekiti State University, College of Medicine, Department of Medical Biochemistry, P.M.B., 5363, Ado Ekiti, Ekiti State, Nigeria temidayo.ogunmoyole@eksu.edu.ng Nigeria
OF
Omotola Grace Fatile Ekiti State University, Department of Science Laboratory Technology, Ado Ekiti, Ekiti State, Nigeria Nigeria
OJ
Olaitan Daniel Johnson Auchi Polytechnic, School of Applied Sciences, Department of Science Laboratory Technology, Auchi, Edo State, Nigeria Nigeria
AY
Adewale Akeem Yusuff Osun State Primary Health Care Board, Department of Medical Laboratory Service, Oshogbo, Osun State, Nigeria Nigeria
Pages196-204 PublishedMay 11, 2022 LicenseOpen Access
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IJPBP 2 VOL 2 · 2
VOL 2 · ISS 2 · 2022 View issue

Abstract

Medicinal potentials of Pergularia daemia leaves in managing hepato-renal toxicity induced by rifampicin were investigated. Twenty-five (25) Wistar rats were randomly placed into five groups containing five animals each. All the animals, except group I, were orally exposed to 250 g/kg bwt rifampicin and administered different treatments. Specific liver and kidney biomarkers such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) were determined. In addition, malondialdehyde (MDA), lipid profile, superoxide dismutase (SOD), catalase (CAT), as well as reduced glutathione (GSH) were determined in the serum, liver, and kidney homogenates of experimental animals. Results indicate that exposure to rifampicin caused significant depletion in SOD and CAT relative to the control animals. Lipid profile was deranged, while ALT, AST, ALP, urea, uric acid, bilirubin, creatine kinase, and MDA level were elevated by rifampicin exposure. All deranged biochemical indices, as well as distorted histoarchitecture, were restored dose-dependently after treatment with P. daemia. In conclusion, P. daemia ameliorated rifampicin toxicity on the liver and kidney as indicated in the restoration of all deranged biochemical and histopathological indices measured. Hence, it is a potential therapeutic agent that can be harnessed as the panacea to the menace of liver and kidney diseases.

Keywords

#Pergularia daemia #Liver #Kidney #Biomarkers #Toxicity #Rifampicin

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