The effects of Quercus (Oak) acorn on cutaneous wound healing in rats

Ahmet Uyar; Gwlshan Mohammed Jhangir; Ömer Faruk Keleş; Zabit Yener

doi:10.29228/ijpbp.27

Authors

Ahmet Uyar Mustafa Kemal University, Faculty of Veterinary Medicine, Department of Pathology, Hatay, Türkiye https://orcid.org/0000-0003-4345-6756
Gwlshan Mohammed Jhangir Yuzuncu Yil University, Faculty of Veterinary Medicine, Department of Pathology, Van, Türkiye https://orcid.org/0009-0008-3422-0606
Ömer Faruk Keleş Yuzuncu Yil University, Faculty of Veterinary Medicine, Department of Pathology, Van, Türkiye https://orcid.org/0000-0002-7869-5311
Zabit Yener Yuzuncu Yil University, Faculty of Veterinary Medicine, Department of Pathology, Van, Türkiye https://orcid.org/0000-0002-6365-5843

DOI:

https://doi.org/10.29228/ijpbp.27

Keywords:

Oak acorn, Epithelization, Wound healing, Rat

Abstract

Quercus spp. (Oak) has been used in traditional medicine due to its medicinal properties for centuries. However, its effect on wound healing in the skin is well unknown. This experimental trial was performed to evaluate in vivo wound healing of Oak acorn in the skin of rats. In the present trial, 24 Wistar albino rats were allocated to three groups equally, control (n = 8), Madecassol® (n = 8), and Oak acorn (n = 8). The circular excision wound models by biopsy punch device were applied in the interscapular region in rats. Oak acorn and Madecassol® pomade have been applied to experimental groups per day and normal saline solution and glycerin have been given to the control group locally as placebo. Blood and skin tissue were collected to evaluate histopathological and biochemical alterations on days 7^th and 15^th. In comparison with the control group, the topical administration of Oak acorn showed definite effects on epithelization, proliferative impacts on fibroblast cells, and enhancing effect on collagen formation by reducing inflammation and edema. Biochemical investigations of skin and blood tissues exhibited that fluctuated malondialdehyde and antioxidant defense system components were rehabilitated in the Oak acorn group. This experimental study revealed that pomade obtained from the Oak acorn displays remarkable wound-healing activity.

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