Natural phenolic compounds from Satureja L. as inhibitors of COVID-19 protease (Mpro): Computational investigations

Faika Başoğlu-Ünal; Selin Tufan; Nur Tan

doi:10.62313/ijpbp.2022.21

Authors

Faika Başoğlu-Ünal European University of Lefke, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Lefke, Northern Cyprus, TR-10 Mersin, Turkey https://orcid.org/0000-0002-4890-3124
Selin Tufan Istanbul University, Faculty of Pharmacy, Department of Pharmacognosy, Beyazıt, Istanbul, Turkey https://orcid.org/0000-0002-9173-3423
Nur Tan Istanbul University, Faculty of Pharmacy, Department of Pharmacognosy, Beyazıt, Istanbul, Turkey https://orcid.org/0000-0001-7958-1917

DOI:

https://doi.org/10.62313/ijpbp.2022.21

Keywords:

Satureja L., Phenolic compounds, COVID-19, Protease inhibitor (Mpro)

Abstract

Coronavirus (SARS-CoV-2) causes a new type of severe acute respiratory syndrome that first appeared in Wuhan in December 2019; it is a very fast-spreading and deadly virus. Therefore, urgent discovery or development of “lead compounds” against this virus is crucial. Natural compounds have always served as a great source, especially the use of traditional medicinal plants, in modern drug discovery. This study aimed to investigate the SARS-CoV-2 protease inhibition potential of the phenolic compounds in the genus Satureja L. The affinities of the chosen natural products were understood using molecular docking simulation against the SARS-CoV-2 protease enzyme. The study proved that three different phenolic compounds namely 5,6-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-7,8-dimethoxy-4H-chromen-4-one, 2-(3,4-dimethoxyphenyl)-5,6-dihydroxy-7,8-dimethoxy-4H-chromen-4-one, and 5,6-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-7,8-dimethoxy-4H-chromen-4-one obtained from Satureja L. taxa were found as promising against SARS-CoV-2 main protease.

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