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International Journal of Plant Based Pharmaceuticals
e‑ISSN 2791-7509 Open Access · CC BY 4.0
Vol. 2 · Issue 1 · 2022 Jan 6, 2022 Research Articles

Natural phenolic compounds from Satureja L. as inhibitors of COVID-19 protease (Mpro): Computational investigations

FB
Faika Başoğlu-Ünal European University of Lefke, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Lefke, Northern Cyprus, TR-10 Mersin, Turkey Turkey
ST
Selin Tufan Corresponding Istanbul University, Faculty of Pharmacy, Department of Pharmacognosy, Beyazıt, Istanbul, Turkey Selin.tufan@istanbul.edu.tr Turkey
NT
Nur Tan Istanbul University, Faculty of Pharmacy, Department of Pharmacognosy, Beyazıt, Istanbul, Turkey Turkey
Pages111-117 PublishedJan 6, 2022 LicenseOpen Access
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IJPBP 1 VOL 2 · 1
VOL 2 · ISS 1 · 2022 View issue

Abstract

Coronavirus (SARS-CoV-2) causes a new type of severe acute respiratory syndrome that first appeared in Wuhan in December 2019; it is a very fast-spreading and deadly virus. Therefore, urgent discovery or development of “lead compounds” against this virus is crucial. Natural compounds have always served as a great source, especially the use of traditional medicinal plants, in modern drug discovery. This study aimed to investigate the SARS-CoV-2 protease inhibition potential of the phenolic compounds in the genus Satureja L. The affinities of the chosen natural products were understood using molecular docking simulation against the SARS-CoV-2 protease enzyme. The study proved that three different phenolic compounds namely 5,6-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-7,8-dimethoxy-4H-chromen-4-one, 2-(3,4-dimethoxyphenyl)-5,6-dihydroxy-7,8-dimethoxy-4H-chromen-4-one, and 5,6-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-7,8-dimethoxy-4H-chromen-4-one obtained from Satureja L. taxa were found as promising against SARS-CoV-2 main protease.

Keywords

#Satureja L. #Phenolic compounds #COVID-19 #Protease inhibitor (Mpro)

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